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ATX-304 SupplementATX-304 is an investigational small-molecule compound being researched for its ability to activate **AMPK (AMP-activated protein kinase)**, a key cellular energy regulator involved in metabolism, fat oxidation, and glucose utilization. Research focuses on its potential to increase energy expenditure, improve metabolic flexibility, enhance mitochondrial function, reduce visceral fat accumulation, and support insulin sensitivity. Preclinical studies have demonstrated reductions in body fat, liver fat, cholesterol, and oxidative stress, while early human trials have reported promising improvements in resting metabolic rate, triglycerides, and markers of metabolic health. ATX-304 is being investigated for obesity, metabolic dysfunction, and fatty liver disease, although larger clinical trials are needed to establish its long-term safety and effectiveness. **ATX-304 remains an investigational compound and is not FDA-approved.**
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ATX-304 SupplementATX-304 is an investigational small-molecule compound being researched for its ability to activate **AMPK (AMP-activated protein kinase)**, a key cellular energy regulator involved in metabolism, fat oxidation, and glucose utilization. Research focuses on its potential to increase energy expenditure, improve metabolic flexibility, enhance mitochondrial function, reduce visceral fat accumulation, and support insulin sensitivity. Preclinical studies have demonstrated reductions in body fat, liver fat, cholesterol, and oxidative stress, while early human trials have reported promising improvements in resting metabolic rate, triglycerides, and markers of metabolic health. ATX-304 is being investigated for obesity, metabolic dysfunction, and fatty liver disease, although larger clinical trials are needed to establish its long-term safety and effectiveness. **ATX-304 remains an investigational compound and is not FDA-approved.**
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ATX-304 SupplementATX-304 is an investigational small-molecule compound being researched for its ability to activate **AMPK (AMP-activated protein kinase)**, a key cellular energy regulator involved in metabolism, fat oxidation, and glucose utilization. Research focuses on its potential to increase energy expenditure, improve metabolic flexibility, enhance mitochondrial function, reduce visceral fat accumulation, and support insulin sensitivity. Preclinical studies have demonstrated reductions in body fat, liver fat, cholesterol, and oxidative stress, while early human trials have reported promising improvements in resting metabolic rate, triglycerides, and markers of metabolic health. ATX-304 is being investigated for obesity, metabolic dysfunction, and fatty liver disease, although larger clinical trials are needed to establish its long-term safety and effectiveness. **ATX-304 remains an investigational compound and is not FDA-approved.**
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ATX-304 SupplementATX-304 is an investigational small-molecule compound being researched for its ability to activate **AMPK (AMP-activated protein kinase)**, a key cellular energy regulator involved in metabolism, fat oxidation, and glucose utilization. Research focuses on its potential to increase energy expenditure, improve metabolic flexibility, enhance mitochondrial function, reduce visceral fat accumulation, and support insulin sensitivity. Preclinical studies have demonstrated reductions in body fat, liver fat, cholesterol, and oxidative stress, while early human trials have reported promising improvements in resting metabolic rate, triglycerides, and markers of metabolic health. ATX-304 is being investigated for obesity, metabolic dysfunction, and fatty liver disease, although larger clinical trials are needed to establish its long-term safety and effectiveness. **ATX-304 remains an investigational compound and is not FDA-approved.**
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ATX-304 SupplementATX-304 is an investigational small-molecule compound being researched for its ability to activate **AMPK (AMP-activated protein kinase)**, a key cellular energy regulator involved in metabolism, fat oxidation, and glucose utilization. Research focuses on its potential to increase energy expenditure, improve metabolic flexibility, enhance mitochondrial function, reduce visceral fat accumulation, and support insulin sensitivity. Preclinical studies have demonstrated reductions in body fat, liver fat, cholesterol, and oxidative stress, while early human trials have reported promising improvements in resting metabolic rate, triglycerides, and markers of metabolic health. ATX-304 is being investigated for obesity, metabolic dysfunction, and fatty liver disease, although larger clinical trials are needed to establish its long-term safety and effectiveness. **ATX-304 remains an investigational compound and is not FDA-approved.**
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Read The Research

The Science Behind ATX-304

What Has Researchers So Interested in This Next-Generation Metabolic Compound?

From cellular energy regulation to fat metabolism and mitochondrial function, ATX-304 is attracting attention in metabolic research.

ATX-304 is an investigational compound studied for its ability to activate AMPK, one of the body's key cellular energy regulators.

Early research has explored its potential influence on metabolic rate, fat oxidation, mitochondrial activity, liver fat, and metabolic health.

And now, researchers are beginning to investigate these effects in humans.



THE HUMAN RESEARCH: A COMPELLING EARLY SIGNAL

Up to 33% Increase in Resting Metabolic Rate Reported

In a small 2026 Phase 1b study involving 23 participants with obesity and prediabetes, researchers investigated ATX-304 over an initial eight-week treatment period.

The preliminary findings included:

Metabolic Rate: Increases of up to 33% from baseline were reported.
Visceral Fat: MRI findings indicated reductions in fat surrounding internal organs.
Liver Fat: Researchers observed reductions in liver fat.
Metabolic Signaling: Changes in adiponectin, a hormone involved in metabolic regulation, were reported.

These are preliminary findings from a small clinical study. The 33% figure represents an upper-end observation, not an average or established treatment effect.

*Source: American Diabetes Association, 2026 — Phase 1b Study of AMPK/Mitochondrial Activator ATX-304.



 BEYOND METABOLISM: WHAT ELSE IS BEING STUDIED?

Fat Metabolism & Liver Health

A 2025 peer-reviewed animal study published in *JCI Insight* found that ATX-304 reduced fat accumulation, cholesterol, liver fibrosis, and oxidative stress in experimental models.

Mitochondrial Energy Regulation

Laboratory studies have examined how ATX-304 influences mitochondrial oxygen consumption, cellular energy balance, and AMPK signaling.

Kidney Protection Research

A 2024 preclinical study investigated ATX-304 in models of chemotherapy-induced kidney injury, reporting reductions in experimental markers of tissue damage.



WHY ATX-304 STANDS OUT IN METABOLIC RESEARCH

Unlike compounds investigated primarily for appetite regulation, ATX-304 is being studied for its effects on cellular energy regulation and metabolic pathways.

Its research spans several interconnected processes:

- AMPK activation
- Mitochondrial energy metabolism
- Fatty acid oxidation
- Liver lipid metabolism
- Cellular oxidative stress

One investigational compound. Multiple areas of metabolic research.

EXPLORE THE ATX-304 RESEARCH

Discover the studies investigating this emerging compound and the science behind its potential metabolic applications.

VIEW ATX-304 — RESEARCH USE ONLY


​*ATX-304 is an investigational research chemical. It is not FDA-approved, and its safety and efficacy for human use have not been established. Animal and laboratory findings should not be interpreted as demonstrated human health benefits. Not for human consumption.*

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